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Statins (HMG-CoA reductase inhibitors) are the drugs of selection for treating hypercholesterolemia. Mechanisms of motion Both CsA and TAC are lipophylic prodrugs that must bind to cytoplasmic receptors, known as immunophilins, to gain pharmacological exercise. The receptor for CsA is known as cyclophilin, and that for TAC known as FK-binding protein 12 (FKBP-12). After binding to the respective cyclophilin, calcineurin inhibitors inhibit the activity of a posh of phosphatases known as calcineurin. The exercise...Read more